Dr. Neeta Sehgal
Department of Zoology
Fish are used as the experimental model for studies investigating how the
actions of hormones, growth factors of ovarian origin and intracellular signal
transduction pathways interact to coordinate ovarian growth and
differentiation. We are beginning to understand some aspects of the dynamics of
follicular development and functional changes that occur as follicles
differentiate, but fundamental questions about follicular development remain to
be answered. Current research focuses on the hormonal control of growth,
atresia and functional competence (in terms of hormone biosynthetic capacity
and responsiveness) of goldfish and trout ovarian follicles during development.
In addition to addressing the relevance of growth factors to ovarian
physiology, localization of sites of synthesis within the ovary and regulation
of their production are being studied.
Awareness that chemicals in the environment affect reproductive performance
of feral fish populations through effects on endocrine homeostasis has led to
the implementation of industrial process changes and waste treatment strategies
designed to eliminate or reduce the release of harmful chemicals to the environment.
As a result, there is a need to develop rapid methods of determining the
effectiveness of technological changes as they pertain to reproductive
endocrine endpoints. On going research focuses on the development of short term
in vitro techniques through to whole animal test methods applicable in lab and
field settings to evaluate the effects of chemicals on reproductive physiology
of fish. The long term goal of this work is to establish whether chemicals
which are identified on the basis of in vitro bioactivity are predictive of
effects in vivo and to determine which endocrine responses are most sensitive
in terms of whole animal and population levels effects.
Dr. NEETA SEHGAL
Education and Positions of
Zoology with specialization in Fish Biology
Lecturer in Zoology with specialization in Fish Biology
in Zoology with specialization in Fish Biology
of Science and Technology