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University of Delhi |
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List of Patents and Publications: |
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1. Thionated cinnamates and process for preparation thereof. Balaram Ghosh, Virinder S. Parmar, Ashok K. Prasad, Brajendra K. Singh, Sarvesh Kumar. Indian Pat. Appl. (2012), IN 2010DE00960 A 20121019. 2. Spiro[indoline-isoxazolidine] compounds having inhibitory effects on cytokine-induced cell adhesion molecule (ICAM-1) expression onto human endothelial cells. Balaram Ghosh, Virinder S. Parmar, Ashok K. Prasad, Brajendra K. Singh, Sakshi Balwani, Shashwat Malhotra Indian Pat. Appl. (2012), IN 2011DE00115 A 20120720. 3. Antiinflammatory and antimicrobial activities of novel carboxychroman amide derivatives. Virinder S Parmar, Balaram Ghosh, Ashok K Prasad, G. L. Sharma, Ajendra K. Sharma, Ashish Dhawan, Brajendra K. Singh, Seema Singh and Sakshi Balwani. Indian Pat. Appl. (filed 2013). 4. Antimicrobial and anti-inflammatory activities of N- protected isatin derivatives. Ashok K Prasad, Balaram Ghosh, Virinder S Parmar, G. L. Sharma, Brajendra K. Singh, Shashwat Malhotra, Seema Singh and Sakshi Balwani. Indian Pat. Appl. (filed 2013). |
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Patents: |
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Publications: |
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1. Acetoxy drug: protein transacetylase: A novel enzyme mediating protein acetylation by polyphenolic peracetates. H. G. Raj, V. S. Parmar, Ekta Kohli, B. S. Dwarkanath, S. C. Jain, R. C. Rastogi, Ajit Kumar, Brajendra K. Singh, J. S. Adhikari, A. C. Watterson and C. E. Olsen. Bioresources Towards Durg Discovery and Development, Editors: A. Guib-Fakim, P. Ramasami, H. Li Kam Wah, S. Jhaumeer-Laulloo and A. H. Subratty. University of Mauritius press, Reduit, 2005, 205-212. 2. Novel thiocoumarins as inhibitors of TNF-a induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation. Sarvesh Kumar, Brajendra K. Singh, Neerja Kalra, Vineet Kumar, A. K. Prasad, H. G. Raj, V. S. Parmar and Balaram Ghosh. Bioorganic and Medicinal Chemistry, 2005, 13, 1605-1613. 3. Acetoxy drug: protein transacetylase: A novel enzyme mediating protein acetylation by polyphenolic peracetates. H. G. Raj, Brajendra K. Singh, V. S. Parmar, Ekta Kohli, B. S. Dwarkanath, S. C. Jain, R. C. Rastogi, Ajit Kumar, J. S Adhikari, A. C. Watterson and C. E. Olsen. Pure and Applied Chemistry, 2005, 77, 245-250. 4. Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase. Ajit Kumar, Brajendra K. Singh, Rahul Tyagi, S. K. Jain, S. K. Sharma, A. K. Prasad, H. G. Raj, R. C. Rastogi and V. S. Parmar. Bioorganic and Medicinal Chemistry, 2005, 13, 4300-4305. 5. Solvent-free biocatalytic amidation of carboxylic acids. A. K. Prasad, Mofazzal Husain, Brajendra K. Singh, R. K. Gupta, V. K. Manchanda, C. E. Olsen and V. S Parmar. Tetrahedron Letters, 2005, 46, 4511-4514. 6. Novel aromatic ester from Piper longum and its analogues inhibit expression of cell adhesion molecules on endothelial cells. Sarvesh Kumar, Pragya Arya, Chandrani Mukherjee, Brajendra K. Singh, Naresh Singh, V. S. Parmar, A. K. Prasad, Balaram Ghosh. Biochemistry, 2005, 44, 15944-15952. 7. Copper (II)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling. Brajendra K. Singh, Prasad Appukkuttan, Stijn Claerhout, V. S. Parmar and Erik Van der Eycken. Organic Letters, 2006, 8, 1863-1866. 8. Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase. Ajit Kumar, Brajendra K. Singh, N. K. Sharma, K. Gyanda, S. K. Jain,Y. K. Tyagi, A. S. Baghel, Mukesh Pandey, S. K. Sharma, A. K. Prasad, S. C. Jain, R. C. Rastogi, H. G. Raj, A. C. Watterson, Erik Van der Eycken and V. S. Parmar. European Journal of Medicinal Chemistry, 2007, 42, 447-455. 9. Chromone analog inhibits TNF-a induced expression of cell adhesion molecules on human endothelial cells via blocking NF-kB activation. Sarvesh Kumar, Brajendra K. Singh, A. K. Pandey, Ajit Kumar, S. K. Sharma, H. G. Raj, A. K. Prasad, Erik Van der Eycken, V. S. Parmar and Balaram Ghosh. Bioorganic and Medicinal Chemistry, 2007, 15, 2952-2962. 10. Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker. Nadya Kaval, Brajendra K. Singh, D. S. Ermolatev, Stijn Claerhout, V. S. Parmar, Johan Van der Eycken and Erik Van der Eycken. Journal of Combinatorial Chemistry, 2007, 9, 446-453. 11. Palladium-catalyzed copper (I)-mediated coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling. Brajendra K. Singh, V. P. Mehta, V. S. Parmar and Erik Van der Eycken. Organic and Biomolecular Chemisrty, 2007, 5, 2962-2965. 12. Transition Metal-Catalyzed Carbon Carbon Bond Formation Suzuki, Heck, and Sonogashira Reactions Using Microwave and Microtechnology. Brajendra K. Singh, Nadya Kaval, Erik Van der Eycken and V. S. Parmar. Org. Process. Res. Dev. 2008, 12, 468-474. 13. Rapid Pd-Catalysed C3-Arylation of 2(1H)-pyrazinones: Effect of Simultaneous Cooling on Microwave-assisted reactions on solid support. Brajendra K. Singh, Virinder S. Parmar and Erik V. Van der Eycken. Synlett, 2008, 3021-3025. 14. Copper-Mediated N- and O- Arylations with Phenlyboronic Acids in a Continuous flow Microreactor. Brajendra K. Singh, Christian V. Stevens, Davy R. J. Acke, Virinder S. Parmar and Erik V. Van der Eycken. Tetrahedron Letters, 2009, 50, 15-18. 15. Microwave-Assisted Silver Carbonate-Mediated Selective O-Alkylation of aromatic imidate systems: Systematic Study of Microwave Irradiation Effect on Nitrogen vs Oxygen Alkylation. Brajendra K. Singh, Claudia Cavalluzzo, Marc De Maeyer, Zeger Debyser, Virinder S. Parmar and Erik Van der Eycken Synthesis 2009, 2725-2728. 16. Microwave Assisted Palladium-Catalyzed Heterogeneous Vinylation of 2(1H)-pyridone. Brajendra K. Singh, Claudia Cavalluzzo, Marc De Maeyer, Zeger Debyser, Virinder S. Parmar and Erik Van der Eycken E. J. Org., 2009, 4589-4592. 17. Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones. Ashok K Prasad, Pragya Arya, Sumati Bhatia, Raman K Sharma, Rishipal Singh, Brajendra K Singh, Erik Van der Eycken, Rajpal Singh, Carl E Olsen and Virinder S Parmar. Indian J. Chem. 2009, 48B, 1738-1748.
Publication after Joining University of Delhi: 1. Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems Morabito Giuseppa, Trombetta Domenico, Brajendra K. Singh, Ashok K. Prasad, Virinder S. Parmar, Naccari Clara, Mancari Ferdinando, Saija Antonina, Cristani Mariateresa, Firuzi Omidreza, Luciano Saso. Biochimie, 2010, 92, 1101-1107. 2. In vitro interactions of coumarins with iron Premysl Mladenka, Katerina Macakova, Libuse Zatloukalova, Zuzana Rehakova, Brajendra K. Singh, Ashok K. Prasad, Virinder S. Parmar, Ludek Jahodar, Radomir Hrdina and Luciano Saso. Biochimie, 2010, 92, 1108-1114. 3. Novel Natural Product-based Cinnamates and Their Thio and thiono-analogs as Potent Inhibitors of Cell Adhesion Molecules on Human Endothelial Cells. Sarvesh Kumar, Brajendra K. Singh, Pragya Arya, Shashwat Malhotra, Rajesh Thimmulappa, Ashok K. Prasad, Erik Van der Eycken, Carl E Olsen, Anthony L. DePass, Shyam Biswal, Virinder S. Parmar and Balaram Ghosh Eur. J. Med. Chem. 2011, 46, 5498-5511. 4. Synthesis and biological activity evaluation of N-protected isatin derivatives as potent inhibitors of ICAM-1 expression on human endothelial cells. Shashwat Malhotra, Sakshi Balwani, Ashish Dhawan, Brajendra K. Singh, Sarvesh Kumar, Rajesh Thimmulappa, Shyam Biswal, Carl E. Olsen, Erik van Eycken Ashok K. Prasad, Balaram Ghosh and Virinder S. Parmar Med. Chem. Comm. 2011, 2, 743-751. 5. Design, synthesis and biological activity evaluation of regioisomeric spiro-(indoline-isoxazolidines) on the inhibition of TNF-a induced ICAM-1 expression on human endothelial cells. Malhotra, Shashwat; Balwani, Sakshi; Dhawan, Ashish; Raunak; Kumar, Yogesh; Singh, Brajendra K.; Olsen, Carl E.; Prasad, Ashok K.; Parmar, Virinder S.; Ghosh, Balaram Med. Chem. Comm. 2012, 3, 1536-1547. 6. Arylalkyl Ketones, Benzophenones, Desoxybenzoins and Chalcones Inhibit TNF-a Induced Expression of ICAM-1: Structure-Activity Analysis. Kumar, Sarvesh; Reddy L, Chandra Shekhar; Kumar, Yogesh; Kumar, Amit; Brajendra K. Singh, Kumar, Vineet; Malhotra, Shashwat; Pandey, Mukesh K.; Jain, Rajni; Thimmulappa, Rajesh; Sharma, Sunil K.; Prasad, Ashok K.; Biswal, Shyam; Van der Eycken, Erik; DePass, Anthony L.; Malhotra, Sanjay V.; Ghosh, Balaram; Parmar, Virinder S. Archiv der Pharmazie 2012, 345, 368-377. 7. De novo design of small molecule inhibitors targeting the LEDGF/p75-HIV integrase interaction. Claudia Cavalluzzo, Arnout Voet, Frauke Christ, Brajendra K. Singh, Ajendra Sharma, Zeger Debyser, Marc De Maeyer, Erik Van der Eycken. RSC Advances 2012, 2, 974-984. 8. A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model. Sarvesh Kumar, Ulaganathan Mabalirajan, Rakhshinda Rehman, Brajendra K. Singh, Virinder S. Parmar, Ashok K. Prasad, Shyam Biswal, Balaram Ghosh. International Immunopharmacology 2013, 15 150-159. 9. Functionalized Hydroxyethylamine Based Peptide Nanostructures As Potential Inhibitors of Falcipain-3, an Essential Proteases of Plasmodium falciparum Brijesh Rathi, Anil K. Singh, Ram Kishan, Neelu Singh, N. Latha, S. Srinivasan, Kailash C Pandey, Hemandra K. Tiwari and Brajendra K. Singh Bioorganic and Medicinal Chemistry, 2013 10. Entry of chiral phthalimides with significant second order nonlinear optical and piezoelectric properties Anil K. Singh, Ram Kishan, N. Vijayan, V. Balachandran, Taruna Singh, Hemandra K Tiwari, Brajendra K Singh and Brijesh Rathi RSC Advances 2013 |