Dr. Savita Sharma

savita

She has done both MSc and BSc from University of Delhi. She has joined Prof. Rajeev Gupta as a PhD student in a project Bio-inspired coordination chemistry at University of Delhi, INDIA. After receiving her PhD degree in 2009, she worked with Dr. Cora E. MacBeth at Emory University as an Post-doctoral fellow. At present, she is working with Prof. Kenneth D. Karlin at John Hopkins University.

Project: Bio-inspired coordination chemistry

Email: ssharma36@jhu.edu

Research Interest

Synthetic models of Heme–Copper oxidases (HCOs, e.g., cytochrome c oxidase,CcO). including detailed studies of molecular oxygen, nitrogen monoxide (NO, also nitric oxide), and oxygen/nitric-oxide interactions with heme-copper and/or heme chemical systems.
To elucidate fundamental aspects of such chemistries as relevant to heme/copper oxidases (HCOs, e.g., cytochrome c oxidase, CcO) and Nitric Oxide Dioxygenases (NOD).

Publications

Critical Aspects of Heme–Peroxo–Cu Complex Structure and Nature of Proton Source Dictate Metal–Operoxo Breakage versus Reductive O–O Cleavage Chemistry, S. M. Adam, I. Garcia-Bosch, A. W. Schaefer, S. K. Sharma, M. A. Siegler, E. I. Solomon, K. D. Karlin, J. Am. Chem. Soc., 2017, 139, 472-481. [PDF]
Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical–Co(II)–Superoxide Complex with Divergent Catalytic Reactivity, A. R. Corcos, O. Villanueva, R. C. Walroth, S. K. Sharma, J. Bacsa, K. M. Lancaster, C. E. MacBeth, J. F. Berry, J. Am. Chem. Soc.,2016, 138, 1796-1799. [PDF]
Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization, S. K. Sharma, H. Kim, P. J. Rogler, M. A. Siegler, K. D. Karlin, J. Biol. Inorg. Chem.,2016, 21, 729-743. [PDF]
Reactions of a heme-superoxo complex toward a cuprous chelate and center dot NO(g): CcO and NOD chemistry, S. K. Sharma, P. J. Rogler, K. D. Karlin, J.Porphyr. Phthalocyanines, 2016, 19, 352-360. [PDF]
A "Naked" Fe-III-(O-2(2-))-Cu-II Species Allows for Structural and Spectroscopic Tuning of Low-Spin Heme-Peroxo-Cu Complexes, I. Garcia-Bosch, S. M. Adam, A. W. Schaefer, S. K. Sharma, R. L. Peterson, E. I Solomon, K. D. Karlin, J. Am. Chem. Soc., 2015, 137, 1032-1035. [PDF]
Peroxynitrite (O= NOO-) generation at metal complex centers via (ligand)-M/NO/O-2 reactivity, K. D. Karlin, S. K. Sharma, R. Cao, Abstracts of Papers of the American Chemical Society, 2014, 248.
A Different Approach to the Synthesis of CcO Model Systems: A" Naked" Heme-Peroxo-Cu (II) Complex Leads to the Formation of Low-Spin Cores With or Without Axial Ligands, I. Garcia-Bosch, R. Peterson, S. Sharma, S. Adam, K. D. Karlin, I. Garcia-Bosch, J. Biol. Inorg. Chem., 2014, 19, S491.
Peroxynitrite Intermediates in Heme/Dioxygen/NO Chemistry, S. K. Sharma, Y. Li, M. P. Schopfer, K. D. Karlin, J. Biol. Inorg. Chem., 2014, 19, S149.
Synthesis and characterization of monometallic and bimetallic first-row transition metal complexes supported by coordinatively versatile ligands, O. Villanueva, S. K. Sharma, K. I. Hardcastle, C. E. MacBeth, Abstracts of Papers of the American Chemical Society, 2013, 245.
Developing redox-active ligand scaffolds for the activation of dioxygen at copper (II) centers, O. Villanueva, S. K. Sharma, K. I. Hardcastle, C. E. MacBeth, Abstracts of Papers of the American Chemical Society, 2013, 245.
New heme–dioxygen and carbon monoxide adducts using pyridyl or imidazolyl tailed porphyrins, Y. Li, S. K. Sharma, K. D. Karlin, Polyhedron, 2013, 58, 190. [PDF]
A Selective Stepwise Heme Oxygenase Model System: An Iron(IV)-Oxo Porphyrin π-Cation Radical Leads to a Verdoheme-Type Compound via an Isoporphyrin Intermediate, I. Garcia-Bosch, S.K. Sharma, K. D. Karlin, J. Am. Chem. Soc., 2013, 135, 16248. [PDF]
Catalytic dioxygen activation of Co(II) complexes employing a coordinatively versatile ligand scaffold, S. K. Sharma, P. S. May, M. B. Jones, S. Lense, K. I. Hardcastle, C. E. MacBeth, Chem. Commun., 2011, 47, 1827. [PDF]
Nickel and copper complexes with few amide-based macrocyclic and open-chain ligands, M. Munjal, S. Kumar, S. K. Sharma, R. Gupta, Inorg. Chim. Acta, 2011, 377, 144. [PDF]
Studies on the structure and properties of nickel complexes in a set of amide-based 13-membered macrocyclic ligands, S. K. Sharma, R. Gupta, Inorg. Chim. Acta, 2011, 376, 95. [PDF]
The effect of ligand architecture on the structure and properties of nickel and copper complexes of amide-based macrocycles, S. K. Sharma, G. Hundal, R. Gupta, Eur. J. Inorg. Chem., 2010, 621. [PDF]
Effect of ligand architecture on the structure and properties of square-planar nickel(II) complexes of amide-based macrocycles, S. K. Sharma, S. Upreti, R. Gupta, Eur.J. Inorg. Chem., 2007, 3247. [PDF]

Dr. Savita Sharma

Research Interest

Publications

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